This is for a novel I'm going to do for NaNoWriMo. It's already started, so I'll be continuing it - as a "NaNo Rebel" if you know what that means. (For those who don't it simply means I won't follow the NaNoWriMo rule about writing a
completely new novel in November.)
Would sort-of-humanoid aliens be the kiss of death?

If I made them sort of humanoid but not "Greys" or "Little Green Men"

? You see, my story has a theme that is more spiritual/religious. It crosses genres in several ways. I want to have action and adventure like a thriller, the concept of aliens but not get bogged down in the "they're like nothing we will have ever seen before" admonitions I've been reading about in books about alien evolution.
In other words, I want them to have sort of a "DNA analogue," and an analogue toward symmetry (probably bilateral), cephalization, be able with help to breathe our atmosphere and communicate with us. Unlike hard SF where the alienness IS the story, I want the alienness to be more of a storytelling device. Like the lightsabers in Star Wars or the magic in Harry Potter. Yet it won't just be space opera or fantasy. Think C.S. Lewis with a little more science feel, perhaps.
Am I making any sense at all?

And more importantly, would you read it?

It may be mostly to the taste of a specialized religious audience (Catholic or at least Judeo-Christian) and I'm fine with the need to create my own niche market of readers. But the question about humanlike aliens could apply to "soft" science fiction works, right?